Depression is a physical illness which could be treated with anti-inflammatory drugs, scientists suggest

Depression could be treated using anti-inflammatory drugs, scientists now believe, after determining that it is a physical illness caused by a faulty immune system.

Around one in 13 people in Britain suffers from anxiety or depression and last year the NHS issued 64.7 million prescriptions for antidepressants, double the amount given out a decade ago.

Current treatment is largely centred around restoring mood-boosting chemicals in the brain, such as serotonin, but experts now think an overactive immune system triggers inflammation throughout the entire body, sparking feelings of hopelessness, unhappiness and fatigue. 

It may be a symptom of the immune system failing to switch off after a trauma or illness, and is a similar to the low mood people often experience when they are fighting a virus, like flu.

A raft of recent papers, and unexpected results from clinical trials, have shown that treating inflammation seems to alleviate depression.

Likewise when doctors give drugs to boost the immune system to fight illness it is often accompanied by depressive mood - in the same way as how many people feel down after a vaccination.

Professor Ed Bullmore, Head of the Department of Psychiatry at the University of Cambridge, believes a new field of ‘immuno-neurology’ is on the horizon.

“It’s pretty clear that inflammation can cause depression,” he told a briefing in London to coincide with this week’s Academy of Medical Sciences FORUM annual lecture which has brought together government the NHS and academics to discuss the issue.

“In relation to mood, beyond reasonable doubt, there is a very robust association between inflammation and depressive symptoms.  We give people a vaccination and they will become depressed. Vaccine clinics could always predict it, but they could never explain it.

“The question is does the inflammation drive the depression or vice versa or is it just a coincidence?

“In experimental medicine studies if you treat a healthy individual with an inflammatory drug, like interferon, a substantial percentage of those people will become depressed. So we think there is good enough evidence for a causal effect.”

Scientists at Cambridge and the Wellcome Trust are hoping to begin trials next year to test whether anti-inflammatory drugs could switch off depression.

“There is evidence to suggest it should work,” added Prof Bullmore.

The immune system triggers an inflammatory response when it feels it is under threat, sparking wide-ranging changes in the body such as increasing red blood cells, in anticipation that it may need to heal a wound soon.

Scientists believe that associated depression may have brought an evolutionary benefit to our ancestors. If an ill or wounded tribal member became depressed and withdrawn it would prevent a disease being passed on.

However a link has taken so long to establish because until recently scientists believed the brain was entirely cut off from the immune system, trapped behind a ‘Berlin Wall’ known as the blood brain barrier.

But recent studies have shown that nerve cells in the brain are linked to immune function and one can have an impact on the other. Around 60 per cent of people referred to cardiologists with chest pain do not have a heart problem but are suffering from anxiety.

One in 13 people in Britain suffers from depression CREDIT: ANNA GOWTHORPE 

Figures also show that around 30 per cent of people suffering from inflammatory diseases such as rheumatoid arthritis are depressed - more than four times higher than the normal population.

Likewise people who are depressed after a heart attack are much more likely to suffer a second one, while the lifespan for people withcancer is hugely reduced for people with mental illness.

“You can’t separate the mind from the body,” said Prof Sir Robert Lechler, President of the Academy of Medical Sciences.

“The immune system does produce behaviour. You’re not just a little bit miserable if you’ve got a long term condition, there is a real mechanistic connection between the mind, the nervous system and the immune system.

“Our model of healthcare is outdated. We have a separation. Mental healthcare is delivered by mental health professionals, psychiatrists, mental health nurses and so on, often in separate premises from where physical health care is delivered and that is simply wrong and we need to find ways to ever more closely integrate and train amphibious healthcare professionals who can straddle this divide.”

Research has also shown that people who have suffered severe emotional trauma in their past have inflammatory markers in their body, suggesting their immune system is constantly firing, as if always on guard against abuse.

This article originally appeared on www.telegraph.co.uk and was written by Sarah Knapton.

Photo by: Photo by Nik Shuliahin on Unsplash

Acupuncture, Anxiety & Depression

As our broadband speeds up and our phones get smarter, some matters regarding our health get overlooked — especially our mental health. Tablets and smart phones have made it more convenient to be connected, but a large number of people still feel disconnected. Fortunately, the Internet also has allowed people to explore the possibilities of trying complementary therapies such as acupuncture.

Acupuncture is an ancient form of traditional Chinese medicine. It works on the principle of stimulating points in the body to correct imbalances in the flow of energy (Qi) through channels known as meridians. This belief is based on the interaction of the five elements (wood, fire, earth, metal and water) and having profound effects on internal organs, which are either yin or yang.

Traditional Chinese medicine also recognizes the mind and body interacting as one, meaning that emotions have a physiological effect on the body. Five emotions are represented by the five elements:

• Water (fear)
• Wood (anger)
• Fire (happiness)
• Earth (worry)
• Metal (grief)

Western medical practitioners traditionally have questioned the validity of traditional Chinese medicines such as acupuncture. More recently, acupuncture has been recognized as a legitimate treatment for some conditions and is growing in popularity.

Anxiety

Anxiety is one of the most common mental illnesses worldwide. Many people suffer some form of anxiety occasionally but others cannot manage this natural response to a stressful situation. When a person experiences a highly stressful or threatening scenario, the mind can be overloaded and fail to develop ways of coping.

Although the symptoms can be as manageable as an ominous feeling in the pit of the stomach, some suffer much worse. Anxiety can trigger the following responses:

• physical, such as an irregular heartbeat
• cognitive, which can cause negative thoughts
• behavioral, which may include uncharacteristic aggression or restlessness
• emotional, such as fear.

Depending on which of these symptoms are suffered, different anxiety disorders may be diagnosed. These include:

• generalized anxiety disorder (GAD)
• panic disorder
• social anxiety disorder
• post-traumatic stress disorder (PTSD)
• obsessive-compulsive disorder (OCD)

There are a variety of causes of anxiety; all have different treatments. A person’s personality, behavior or thinking style can cause them to be more susceptible to anxiety. Research has proven it also can be hereditary. Biochemical factors such as a chemical imbalance in the brain also has been proven to cause anxiety.

Traditional Chinese medicine relates anxiety to an imbalance of the heart and kidney. Fire represents the heart and joy according to the five elements. The diagnosis is that too much heat in the heart will imbalance the interaction with the kidney (represented as water and fear). This will result in the water organ failing to contain the fire organ rising up to the mind, leading to anxiety. Acupuncture on points around the heart, kidney, spleen and ear are used to treat anxiety.

In a comprehensive literature review appearing in a recent edition of CNS Neuroscience and Therapeutics, it was proved that acupuncture is comparable to cognitive-behavioral therapy (CBT), which psychologists commonly use to treat anxiety (Errington-Evans, 2011). Another study published in the Journal of Endocrinology in March 2013 discovered stress hormones were lower in rats after receiving electric acupuncture (Eshkevari, Permaul and Mulroney, 2013).

Depression

It is estimated that approximately one in five people will experience clinical depression at least once in their lifetime. Although it is natural to feel sad and down at times, especially after experiencing loss, these slight effects can be managed with gradual lifestyle adjustments. Clinical depression, however, refers to a long-lasting and intense emotional, physical and cognitive state that greatly affects day-to-day life. Symptoms include:

• Loss of positive associations and sense of achievement (lack of interest in normally pleasurable activities)
• Negative thoughts (often worrying about the future)
• Irritability, agitation and exhaustion
• Changes in sleeping patterns (too much or too little)
• Hopelessness (feeling trapped or suicidal)

The causes of depression are known to be similar to the causes of anxiety. It is traditionally treated with antidepressantmedication, psychological methods or a combination of both.

Depression is considered to be a problem with circulating Qi around your body, according to traditional Chinese beliefs. The main organ responsible for circulating Qi is recognized as the liver with the heart and spleen playing supporting roles. The most common acupuncture treatment used to increase the flow of Qi is known as The Four Gates. This involves stimulating source points on both hands between the thumb and index finger and both feet between the big toe and second toe.

Anxiety and depression remain two of the most common mental disorders worldwide. As further research continues, acupuncture and other forms of complementary therapies are gradually being proved to be legitimate treatments for anxiety, depression and other illnesses. Perhaps more important than anything for our health is varying our lifestyles by trying alternative therapies, including exercise, yoga and meditation. It is important, however, to always get a second opinion and consult a doctor any time complementary therapies are tried.

References

Errington-Evans, N. (2011). Acupuncture for anxiety. CNS Neuroscience and Therapeutics, 18(4), 277-284. doi: 10.1111/j.1755-5949.2011.00254.x

Eshkevari, L., Permaul, E., & Mulroney, S.E. (2013). Acupuncture blocks cold stress-induced increases in the hypothalamus–pituitary–adrenal axis in the rat. Journal of Endocrinology, 217(1), 95-104. doi: 10.1530/JOE-12-040

This article originally appeared on psychcentral.com and was written by Nada Ljubinovic



BOOK YOUR APPOINTMENT WITH OUR ACUPUNCTURIST CELINE SANDBERG, R.Ac, SPECIALIZING IN MENTAL HEALTH ACUPUNCTURE TREATMENTS.

What Flotation Therapy Can Do For Depression

Study Demonstrates What Flotation Therapy Can Do For Depression, Stress, Anxiety & More

A study published in the journal BMC Complementary and Alternative Medicine explores sensory deprivation in a flotation tank as a form of preventative healthcare. Its results showed substantial reductions in levels of stress, anxiety, depression, and pain, and along with improved sleep quality and overall mood, proving that flotation therapy is an excellent way to prevent and treat many  emotional and physical ailments.

Sensory deprivation cuts off all the senses from the mind, removing it from the average barrage of stressful situations that most of us face each day. In the absence of distracting external stimuli, the mind enters a state of deep relaxation and meditation. The research shows how this state can actually be medicinal, as it has tremendous potential to reduce stress and thus the damaging symptoms that come with it.

Chronic stress expresses itself through things like depression, insomnia, and anxiety. Flotation therapy can directly relieve this, but how?

The relaxation response method (RR) is essentially the exact opposite of the fight-or-flight response. It is the physiological process that relieves stress, occurring during states of deep relaxation. RR is able to combat stress so efficiently because of its calming effects on the parasympathetic nervous system, the portion of the nervous system responsible for many physiological changes within the body including energy conservation and deep relaxation. It is through this process that RR lowers heart rate and blood pressure and slows down breathing.

The authors of the study noted that to successfully ignite the RR response while the body is under stress it is crucial to reduce all sensory input and movement by the body — which makes floatation therapy the perfect solution. The research described the mechanisms of this method: “During flotation-REST (Restricted Environmental Stimulation Technique) an individual lay in a horizontal floating posture immersed in highly concentrated salt water (magnesium sulphate) in a flotation tank. All incoming stimuli are reduced to a minimum during this period (usually 45 minutes), i.e. sound and light, and the water is heated to skin temperature. ”

The Study

Sixty-five participants — 14 men and 51 women — took part in the study. The participants were divided into a flotation-REST group, which consisted of 37 people, and a wait-list control group, with 28 people. The flotation group received 12 45-minute sessions over the course of seven weeks. Subjects were assessed for depression, anxiety, stress, sleep quality, energy, pain, and optimism before and after the study. These same measurements were assessed for the control group.

The flotation group displayed radically improved scores in comparison to the control group, with participants exhibiting reduced anxiety, depression, pain, and stress.

Here’s Some Data

The average score for stress before flotation treatment was 1.86; afterwards, it dropped to a remarkable 0.95. The control group scored 1.84 before and 1.89 after treatment, meaning their stress actually increased during this period.

The score for anxiety for the flotation group was 7.92 before treatment and 4.28 afterwards. On the other hand, the control group scored 7.03 before and 6.96 afterwards.

For depression, the flotation group started out with a score of 4.42, which then dropped to 2.25 after treatment. The control group started at 4.00 and ended the period at 4.30, another increase.

Researchers also saw an improvement in various lifestyle factors. Sleep quality, pain, optimism, and mindfulness were all measured and shown to increase with treatment. These results further strengthen the case for flotation therapy.

In the conclusion of the study the researchers were confident that flotation therapy can be an excellent practice to improve overall health by greatly reducing stress (and thereby stress related illnesses) while increasing psychological factors in healthy participants as well.

Final Thoughts

Isn’t it just amazing what a little bit of rest and relaxation can do for our mental and physical well-being? While it’s easy to say we should all just make the time to relax more, the issue here is that many of us won’t. If you actually make the effort to go to a float spa, which are becoming increasingly popular across North America, then you will be dedicating this time to yourself and will experience the ultimate form of relaxation. In fact, flotation therapy is one of the most potent methods of activating the relaxation response, and shows how our environment can directly impact our physiological and psychological well-being. Instead of taking prescription drugs for such ailments, consider giving this a try!

This article originally appeared on collective-evolution.com and was written by Alanna Ketler